Aciphex Sprinkle Drug Interactions

Aciphex Sprinkle Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Aciphex Sprinkle is combined with any of the drugs listed above.
 
Atazanavir
Aciphex Sprinkle may decrease the absorption of atazanavir into the bloodstream, making it less effective. It is generally recommended that people taking atazanavir not take Aciphex Sprinkle or any proton pump inhibitor (PPI) medication if at all possible. If your healthcare provider recommends you take these medicines together, you may need to be monitored more closely.
 
Bosutinib
Stomach acid is needed to absorb bosutinib from the stomach into the bloodstream. Medicines that reduce stomach acid, such as Aciphex Sprinkle, can reduce bosutinib blood levels. Talk to your healthcare provider before taking these medicines together.
 
Cefditoren
Aciphex Sprinkle can reduce blood levels of cefditoren, potentially making it less effective. If possible, these medications should not be taken together. Therefore, you should talk to your healthcare provider before taking Aciphex Sprinkle during cefditoren treatment.
 
Certain Antifungal Medications
Certain antifungal medications are best absorbed into the body when there is acid in the stomach. Medications that decrease stomach acid, such as Aciphex Sprinkle, can decrease blood levels of these antifungals, making them less effective. If possible, these drugs should not be taken together. If your healthcare provider recommends you combine these products, you may need to be monitored more closely.
 
Certain Diuretics
Aciphex Sprinkle can cause low blood magnesium (hypomagnesemia). Certain diuretics ("water pills") can also cause low blood magnesium. Thus, taking Aciphex Sprinkle with one of these drugs could cause extremely low blood magnesium levels, potentially leading to serious problems such as muscle spasms, irregular heart rhythms, or seizures. Your healthcare provider may decide to monitor your magnesium levels periodically if you are taking Aciphex Sprinkle with one of these diuretics.
 
Clopidogrel
Aciphex Sprinkle is a proton pump inhibitor (PPI). Research suggests that some other PPIs may decrease the effectiveness of clopidogrel. This could potentially be a serious drug interaction. However, in studies, it appears that Aciphex Sprinkle probably does not interact with clopidogrel. Nevertheless, it is a good idea to discuss this with your healthcare provider before combining these medications. 
 
Dasatinib
Stomach acid is needed to absorb dasatinib from the stomach into the bloodstream. Medicines that reduce stomach acid, such as Aciphex Sprinkle, can reduce dasatinib blood levels. It is generally recommended that these medications not be taken together. Therefore, you should talk with your healthcare provider before combining them.
 
Delavirdine
Aciphex Sprinkle may decrease the amount of delavirdine absorbed into the body, possibly making it less effective. It is generally recommended that these medications not be taken together. Therefore, you should speak with your healthcare provider before combining them.
 
Digoxin
Aciphex Sprinkle may increase blood levels of digoxin. In most cases, this does not cause any problems, and adjustments to your digoxin dosage are usually not needed. However, if you take these medicines together, your healthcare provider may choose to monitor your digoxin levels using a simple blood test, especially when you start or stop taking Aciphex Sprinkle.
 
Erlotinib
Stomach acid is needed to absorb erlotinib from the stomach into the bloodstream. Medicines that reduce stomach acid, such as Aciphex Sprinkle, can reduce erlotinib blood levels. It is generally recommended that these drugs not be taken together. Talk with your healthcare provider before combining them.
 
Iron
Aciphex Sprinkle may decrease the absorption of iron into the bloodstream. Talk with your healthcare provider before taking these products together. You may need to be monitored more closely, especially if you are taking iron for anemia.
 
Mesalamine
Certain mesalamine products are specially coated so that the drug is released from the tablet or capsule in the colon (where it is intended to work) instead of the stomach. Because Aciphex Sprinkle reduces stomach acid, it can cause the drug to be released prematurely into the stomach. This interaction is only a potential concern with mesalamine that is taken by mouth. Talk with your healthcare provider before taking these medications together.
 
Methotrexate
Aciphex Sprinkle may increase blood levels of methotrexate, possibly increasing the risk for side effects. This interaction is more likely a concern when methotrexate is used in high doses, such as when it is used to treat cancer.
 
Nelfinavir
Aciphex Sprinkle can decrease the level of nelfinavir in your blood. It is generally recommended that these medications not be taken together if at all possible. Talk to your healthcare provider before combining these products.
 
Nilotinib
Stomach acid is needed to absorb nilotinib from the stomach into the bloodstream. Medicines that reduce stomach acid, such as Aciphex Sprinkle, can reduce nilotinib blood levels. Talk with your healthcare provider before taking these drugs together.
 
Ponatinib
Stomach acid is needed to absorb ponatinib from the stomach into the bloodstream. Medicines that reduce stomach acid, including Aciphex Sprinkle, can reduce ponatinib blood levels. These medicines should not be taken together if at all possible. Therefore, you should talk to your healthcare provider before combining them.
 
Rilpivirine
Aciphex Sprinkle and other PPIs can reduce rilpivirine blood levels and should not be taken with rilpivirine. Talk to your healthcare provider before combining these medications.
 
Tacrolimus
Aciphex Sprinkle may increase tacrolimus blood levels, potentially increasing your risk for side effects. If you take these medications together, your healthcare provider may monitor you more closely and may need to adjust your tacrolimus dosage.
 
Vismodegib
Medications that reduce stomach acid, such as Aciphex Sprinkle, may reduce the amount of vismodegib absorbed into the bloodstream. Talk with your healthcare provider before taking these medications together.
 
Warfarin
Medications like Aciphex Sprinkle may increase the effects of warfarin, which could increase the risk of bleeding. If you take warfarin, your healthcare provider should monitor your international normalized ratio (INR) more closely, especially when you start or stop taking Aciphex Sprinkle.
 
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Aciphex Sprinkle Medication Information

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