Aciphex Precautions and Warnings

There are some Aciphex precautions and warnings that pertain to certain groups of people, including women who are pregnant and people with liver disease. Pregnant women should talk to their healthcare provider before using Aciphex. You should not take Aciphex if you are allergic to any component of the drug or if you are allergic to any of the ingredients used to make this product.

Aciphex: What Should I Tell My Healthcare Provider?

Prior to taking Aciphex® (rabeprazole sodium), you should tell your healthcare provider if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Low blood magnesium (hypomagnesemia) 
  • Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Also, tell your healthcare provider about all the medicines you take, including prescription and nonprescription medications, vitamins, and herbal supplements.

Some Aciphex Precautions and Warnings

Some precautions and warnings to be aware of with Aciphex include the following:
  • Studies indicate that people who take proton pump inhibitor medications (such as Aciphex) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 


  • Aciphex can interact with certain medications (see Aciphex Drug Interactions).
  • Aciphex is considered a pregnancy Category B medication, which means that it is probably safe for use during pregnancy, although the full risks are currently unknown (see Aciphex and Pregnancy).
  • If you have severe liver disease, your healthcare provider may use caution when treating you with Aciphex.


  • Proton pump inhibitors (PPIs), including Aciphex, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. 


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Aciphex Medication

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