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Drug Interactions With Cimetidine (Cont.)

 
Nifedipine (Adalat, Nifediac, Procardia, Procardia XL)
Cimetidine can increase the amount of nifedipine in your blood, increasing your chance of side effects. Your healthcare provider may need to decrease your nifedipine dosage. Alternatively, your healthcare provider may suggest using one of the alternatives to cimetidine.
 
Phenytoin (Dilantin)
Cimetidine can increase the amount of phenytoin in your blood, increasing your chance of side effects. Your healthcare provider may need to decrease your phenytoin dosage. Alternatively, your healthcare provider may suggest using one of the alternatives to cimetidine.
 
Propranolol (Inderal, Inderal LA, InnoPran XL)
Cimetidine can increase the amount of propranolol in your blood, increasing your chance of side effects. Your healthcare provider may need to decrease your dose of propranolol. Alternatively, your healthcare provider may suggest using one of the alternatives to cimetidine.
 
Theophylline
Cimetidine can increase the amount of theophylline in your blood, increasing your chance of side effects. Your healthcare provider should monitor the level of theophylline in your blood and may need to decrease your theophylline dosage. Alternatively, your healthcare provider may suggest using one of the alternatives to cimetidine.
 
Tricyclic Antidepressants
Cimetidine can increase the level of tricyclic antidepressants in your blood, increasing your chance of side effects. Your healthcare provider may need to decrease your tricyclic antidepressant dose. Alternatively, your healthcare provider may suggest using one of the alternatives to cimetidine.
 
Warfarin (Coumadin, Jantoven)
Taking warfarin and cimetidine together can increase the amount of warfarin in your blood and may increase your risk of bleeding. Your healthcare provider may need to monitor you more closely when starting or stopping cimetidine and may need to adjust your warfarin dose. Alternatively, your healthcare provider may suggest using one of the alternatives to cimetidine.
 
(Drug Interactions With Cimetidine Continued: Page 4)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;