Dexilant Warnings and Precautions

Before taking Dexilant, tell your healthcare provider about any medical conditions you have, such as liver disease or any allergies. Other precautions and warnings with Dexilant apply to women who are pregnant or breastfeeding. This medication can cause drug interactions, so it's important that your healthcare provider is aware of all other medicines you are taking, including nonprescription products.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Dexilant™ (dexlansoprazole) if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Low blood magnesium (hypomagnesemia) 
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Dexilant

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Studies indicate that people who take proton pump inhibitor medications (such as Dexilant) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 



  • Proton pump inhibitors (PPIs), including Dexilant, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. 


  • Dexilant can interact with other medications (see Dexilant Drug Interactions).
  • Dexilant is considered a pregnancy Category B medication. This means that this medicine is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using Dexilant during pregnancy (see Dexilant and Pregnancy).
  • It is unknown if Dexilant passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Dexilant and Breastfeeding).

Dexilant Medication Information

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