Licorice

Licorice comes in the form of candies, beverages, foods, and as a dietary supplement. When used as a supplement, it can help treat a variety of conditions, such as ulcers, heartburn, or indigestion. It can also decrease testosterone production in men and have estrogen-like effects in some situations. Licorice may cause certain side effects, such as heart failure, muscle damage, and changes in blood pressure.

 

What Is Licorice?

Although it is most commonly known for its use in candies, beverages, and foods, licorice is also used as a dietary supplement for treating various medical conditions. It should be noted that many "licorice" candies and other products contain little or no licorice root; instead, they contain anise flavoring (which tastes much like licorice), but they do not have any of the effects of real licorice.
 
(Click Benefits of Licorice for more information.)
 

How Does Licorice Work?

Licorice has many different effects on the human body, some desirable and some not.
 One component in particular, known as glycyrrhizin, is responsible for many of the negative effects of licorice, such as high blood pressure and low blood potassium.
 
On the other hand, licorice may work for treating ulcers or other similar problems, such as heartburn or indigestion, by blocking the breakdown of prostaglandins, substances that help protect the stomach. This effect does not seem to be related to the glycyrrhizin component.
 
Licorice may also affect certain hormones and hormone receptors. It can have estrogen-like properties in some situations and anti-estrogen properties in other situations (this is possibly related to the dose of licorice). Licorice also decreases testosterone production in men.
 
In addition, licorice contains flavonoids (plant compounds), which may have many beneficial effects, such as lowering cholesterol.
 

Is Licorice Effective?

Early research suggests that licorice may be effective at treating a number of different health conditions (see Does Licorice Work?).
 

Dosing Information for Licorice

It is difficult to recommend a licorice "dosage," as research is still in its early stages and a safe and effective dose has not yet been established (see Licorice Dosage for more information).
 

Side Effects of Licorice

As innocuous as it seems, licorice can actually cause some very serious side effects, such as:
 
(Click Licorice Side Effects to learn more, including other potentially serious side effects that you should report immediately to your healthcare provider.)
 

Drug Interactions With Licorice

Licorice can potentially interact with several medications (see Licorice Drug Interactions).
 

Safety Issues With Licorice

Licorice use can be quite dangerous for some people. Therefore, you should talk with your healthcare provider prior to taking it if you have:
 
Also, let your healthcare provider know if you are:
 
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Click Is Licorice Safe? for more information, including any available warnings and precautions.)
 

What If I Take an Overdose of Licorice?

An overdose of licorice can cause serious problems. An overdose may be possible if you take too much licorice all at once or if you consume too much licorice on a daily basis. If you think you may have taken too much licorice, seek immediate medical attention.
 
(Click Licorice Overdose for more information.)
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;