If you have gastroesophageal reflux disease (GERD), your healthcare provider may prescribe Aciphex Sprinkle. This medication is available as a capsule that is taken once a day. Your individual dose will depend on your weight and how you respond to the drug. Side effects are possible and can include diarrhea, headaches, and abdominal (stomach) pain.
Aciphex Sprinkle contains the same active ingredient as regular Aciphex (rabeprazole sodium). Regular Aciphex is approved to treat GERD in children 12 years of age and older, as well as adults. It is also approved for the treatment of several other conditions within the esophagus, stomach, and intestines in adults (see What Is Aciphex Used For? for information about regular Aciphex).
Aciphex Sprinkle is made by Eisai, Inc., and marketed by Janssen Pharmaceuticals, Inc.
How Does Aciphex Sprinkle Work?
The stomach contains tiny pumps called proton pumps. These proton pumps produce acid. Aciphex Sprinkle works by binding to the proton pumps and preventing them from producing acid. PPIs are very effective at decreasing acid production, as they work directly at the acid pumps.
Aciphex Sprinkle capsules contain tiny, delayed-release granules that contain the medication. These granules are enteric coated, which means they have a special coating on them to protect them from stomach acid that can destroy the medication. This coating protects the medication as it passes through the stomach to the small intestine, where it is absorbed into the bloodstream.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Aciphex Sprinkle [package insert]. Woodcliff Lake, NJ: Eisai, Inc.;2013 March.
Aciphex [package insert]. Woodcliff Lake, NJ: Eisai, Inc.;2013 April.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed April 18, 2013.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed April 19, 2013.
National Library of Medicine (US). Hazardous Substances Data Bank (HSDB). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB. Accessed April 19, 2013.
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