GERD Home > Aciphex Side Effects

The most common side effect of Aciphex is headache. Other possible side effects include vomiting, nausea, and diarrhea. In postmarketing experience, a number of other side effects have been reported, including anemia, yellow skin, and pneumonia. However, it's hard to say any of these symptoms are actual side effects of the drug or merely a coincidence.

An Introduction to Aciphex Side Effects

As with any medicine, there are possible side effects with Aciphex® (rabeprazole sodium). However, not everyone who takes Aciphex will experience side effects. In fact, most people tolerate the drug well. When people do develop side effects, the symptoms are usually minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Aciphex. Your healthcare provider can discuss a more complete list of Aciphex side effects with you.)

Possible Side Effects of Aciphex

Aciphex has been studied extensively in clinical trials, with over 1,000 people worldwide having been evaluated. In these studies, side effects occurring in a group of people taking the drug are documented.
Based on these studies, the most common side effects of Aciphex included:
  • Headaches -- up to 9.9 percent of people
  • Diarrhea -- up to 4.5 percent
  • Nausea -- up to 4.5 percent
  • Vomiting -- up to 3.6 percent
  • Abdominal pain (stomach pain) -- up to 3.6 percent
  • Pain (the type of pain was not specified) -- up to 3 percent
  • Sore throat -- up to 3 percent
  • Flatulence -- up to 3 percent
  • Infection -- up to 2 percent
  • Constipation -- up to 2 percent.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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