Axid is an H2 blocker that works by blocking a specific kind of histamine receptor. Histamine is a chemical released by the body that has several effects. In the stomach, histamine causes more acid to be produced. By blocking histamine in the stomach, Axid reduces the amount of acid produced by the stomach. This is why it is known as an "acid reducer."
Effects of Axid
Several studies have looked at how well Axid treats ulcers and GERD.
In one study of Axid for duodenal ulcers (upper intestinal ulcers), they were healed in 68 percent of people who took the medication after four weeks of treatment. Only 29 percent of people who were not taking it had their duodenal ulcer heal within four weeks. After eight weeks, as many as 82 percent of people taking the drug experienced ulcer healing, compared to just 49 percent of those not taking it. Studies have also shown that Axid can prevent duodenal ulcers from returning.
In a study looking at Axid for gastric ulcer (stomach ulcer) treatment, 70 percent of people taking the drug experienced stomach ulcer healing within eight weeks. Ulcers healed in 52 percent of people who were not taking it.
GERD and Esophagitis
There have been studies looking at Axid as a treatment for gastroesophageal reflux disease (GERD). In these studies, people taking the drug had greater relief of their GERD symptoms (including heartburn symptoms), compared to people not taking it. In these studies, the medicine also helped to heal esophagitis (damage to the esophagus) due to GERD.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed December 23, 2009.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed March 6, 2007.
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