Available only by prescription, Dexilant is approved to treat conditions such as gastroesophageal reflux disease (GERD) and erosive esophagitis. The medicine comes in capsule form and is taken once a day. It works by decreasing acid production in the stomach. Although most people tolerate this medicine well, side effects are possible and may include diarrhea, nausea, and vomiting.
What Is Dexilant?
Dexilant™ (dexlansoprazole) is a prescription medication approved to treat gastroesophageal reflux disease (GERD) and erosive esophagitis, a severe form of GERD in which the lining of the esophagus becomes inflamed and ulcerated. Dexilant was previously sold under the name Kapidex™, but the name was changed because it was too similar to the names of a few other drugs (leading to a few "mix-ups").
Dexilant is made by Takeda Pharmaceuticals North America, Inc.
How Does Dexilant Work?
Dexilant belongs to a group of medications called proton pump inhibitors (PPIs). The stomach contains tiny pumps (called proton pumps) that produce acid. Dexilant works by binding to the proton pumps, stopping them from producing acid. PPIs are very effective at decreasing acid production, as they work directly at the acid pumps.
Dexilant capsules contain tiny, delayed-release granules that contain the medication. They are specially designed to release the medication in two different phases. The first "peak" occurs one to two hours after the medication is taken, and the second peak occurs within four to five hours.
Additionally, the delayed-release granules are also enteric coated, which means they have a special coating to protect them from stomach acid (as the medication can be destroyed by stomach acid). The coating protects the medication until it reaches the small intestine, where the medication can be absorbed.
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Clinical Pharmacology [database online]. Drug Interaction Report. Tampa, FL: Gold Standard, Inc.; 2010. Available at: http://www.clinicalpharmacology.com. Accessed March 17, 2011.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed March 30, 2010.
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