The following sections explain in detail the potentially negative interactions that can occur when Nexium is combined with any of the drugs listed above.
Certain Antifungal Medications
Combining Nexium with certain antifungals may decrease the effectiveness of the antifungal (due to decreased absorption) and may also increase the level of Nexium in the blood. Check with your healthcare provider before taking these medications together.
Nexium may increase the level of cilostazol in the blood. If you must take these two medications together, your healthcare provider should consider lowering your cilostazol dosage (to perhaps 50 mg twice daily).
Some research suggests that proton pump inhibitors (PPIs), like Nexium, may decrease the effectiveness of clopidogrel. This could potentially be a serious drug interaction. However, experts are still in disagreement about how significant this interaction really is and whether it applies to all PPIs. Do not combine these medications without discussing the matter with your healthcare provider first.
Nexium may decrease the absorption of dasatinib, perhaps making it less effective. Your healthcare provider may recommend an alternative to Nexium while you are taking dasatinib.
When taking Nexium with diazepam, your body may metabolize the medicines differently than intended, although it is not believed to be significant. You may wish to discuss this with your healthcare provider, prior to starting Nexium.
Nexium may slightly increase the level of digoxin in the blood. Your healthcare provider may choose to monitor you more closely. Nexium may cause low blood magnesium levels, which can lead to serious arrhythmias (irregular heart rhythms), especially in people taking digoxin. Your healthcare provider may decide to monitor your magnesium levels periodically if you are taking digoxin and Nexium.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Nexium [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP;2012 January.
Food and Drug Administration. FDA drug safety communication; low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs) (3/2/11). FDA Web site. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm245011.htm. Accessed March 17, 2011.
Clinical Pharmacology [database online]. Drug Interaction Report. Tampa, FL: Gold Standard, Inc.; 2010. Available at: http://www.clinicalpharmacology.com. Accessed March 17, 2011.
Lexi-Interact [computer program]. Lexi-Comp, Inc.; April 16, 2010.
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