GERD Home > More Products That Interfere With Nexium
Nexium can cause low blood magnesium (hypomagnesemia). Because certain diuretics can also cause this problem, combining Nexium with one of these diuretics could cause severely low blood magnesium levels, which may lead to serious side effects such as muscle spasms, irregular heart rhythms, or seizures. Your healthcare provider may decide to monitor your magnesium levels periodically if you are taking Nexium with one of these diuretics.
Nexium may decrease the absorption of erlotinib, perhaps making it less effective. Your healthcare provider may recommend an alternative to Nexium while you are taking erlotinib.
Nexium may decrease the absorption of iron supplements and medications, since stomach acid is necessary for iron absorption. If you need to take iron for a medical reason (such as for anemia), your healthcare provider may recommend an alternative to Nexium.
Nexium may interfere with the delayed-release mechanism of Apriso capsules, perhaps making Apriso less effective. This is not thought to be a problem with other mesalamine products. In general, these medications should not be taken together.
Nexium might increase the level of methotrexate in the blood, increasing the risk for methotrexate side effects. Check with your healthcare provider before combining these two medications.
Rifampin may significantly decrease the level of Nexium in the blood, making it less effective. These medications should not be combined.
Some Protease Inhibitors
Nexium may decrease the level of atazanavir or nelfinavir in the blood. It may increase the level of saquinavir in the blood. If you take a protease inhibitor, check with your healthcare provider before taking Nexium. In many situations, Nexium will not be recommended.
St. John's Wort
St. John's wort may significantly decrease the level of Nexium in the blood, making it less effective. These medications should not be combined.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Nexium [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP;2012 January.
Food and Drug Administration. FDA drug safety communication; low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs) (3/2/11). FDA Web site. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm245011.htm. Accessed March 17, 2011.
Clinical Pharmacology [database online]. Drug Interaction Report. Tampa, FL: Gold Standard, Inc.; 2010. Available at: http://www.clinicalpharmacology.com. Accessed March 17, 2011.
Lexi-Interact [computer program]. Lexi-Comp, Inc.; April 16, 2010.
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