Nexium may increase the level of tacrolimus in the blood. Your healthcare provider may want to monitor your tacrolimus levels more closely when you start or stop Nexium, particularly for the oral form of tacrolimus (rather than for the skin ointment form).
It is possible that Nexium could increase your risk of bleeding due to warfarin. Your doctor may choose to monitor your INR and prothrombin time more frequently, and adjust your warfarin dosage accordingly.
It is possible that not all drug interactions with Nexium were discussed in this article. Therefore, you should talk with your doctor about any specific drug interactions with Nexium that may apply to you.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Nexium [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP;2012 January.
Food and Drug Administration. FDA drug safety communication; low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs) (3/2/11). FDA Web site. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm245011.htm. Accessed March 17, 2011.
Clinical Pharmacology [database online]. Drug Interaction Report. Tampa, FL: Gold Standard, Inc.; 2010. Available at: http://www.clinicalpharmacology.com. Accessed March 17, 2011.
Lexi-Interact [computer program]. Lexi-Comp, Inc.; April 16, 2010.
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