GERD Home > More Information on Nizatidine Indications

Nizatidine for GERD
Gastroesophageal reflux disease (GERD) is caused by acid reflux into the esophagus. Acid reflux is a term meaning the backward flow of stomach acid into the esophagus. The stomach is designed to be able to handle the acid it produces; the esophagus, however, is not. If too much stomach acid is in contact with the esophagus for too long, damage to the lining of the esophagus occurs, causing the symptoms of GERD (see What Is GERD?).
A few of the more common GERD symptoms include heartburn, the sensation that food is stuck in your throat, choking feelings, an acidic or sour taste in the mouth, and chest pain. Nizatidine is approved to treat the symptoms of GERD. It works by decreasing the amount of acid in the stomach.
Nizatidine also works to heal esophagitis (damage to the esophagus) caused by GERD.

How Nizatidine Works

Nizatidine is part of a class of drugs known as H2 blockers. The medicine works by blocking a certain type histamine receptors (Type 2). Histamine is a chemical that has several different effects in the body. In the stomach, histamine causes the stomach to increase its production of stomach acid. By blocking histamine in the stomach, nizatidine decreases stomach acid production. In addition to decreasing the amount of stomach acid produced throughout the day, nizatidine also helps control the increase in stomach acid that usually happens after meals.

Is Nizatidine Used in Children and Adolescents?

Prescription nizatidine oral solution (liquid) is approved to treat GERD (and heartburn or esophagitis associated with GERD) in children ages 12 and up. Over-the-counter nizatidine AR is approved to treat sour stomach, acid indigestion, and heartburn in children ages 12 and up.
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Last reviewed by: Kristi Monson, PharmD;
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