GERD Home > Pepcid Warnings and Precautions

Among the conditions that you should tell your healthcare provider about before you take Pepcid are kidney problems and any allergies you may have. Some other precautions and warnings with Pepcid include potential drug interactions, the safety of taking Pepcid while pregnant or breastfeeding, and people who should not take this medicine at all (such as those who are allergic to Pepcid or any of its components). Talk with your healthcare provider about any Pepcid warnings and precautions that may apply to you.

Pepcid: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Pepcid® (famotidine) if you have:
  • Kidney problems, such as kidney failure (renal failure)
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
You should also be sure to tell your healthcare provider about all of the medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Pepcid Warnings and Precautions

Following are some warnings and precautions to be aware of before you take Pepcid:
  • Pepcid can interact with certain other medications (see Pepcid Drug Interactions).
  • Pepcid is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy. However, because Pepcid has not been studied in pregnant women, the full risks of using it during pregnancy are not known. Talk with your healthcare provider about the risks and benefits of using Pepcid during pregnancy (see Famotidine and Pregnancy for more information).
  • Pepcid passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider before using Pepcid (see Famotidine and Breastfeeding for more information).
  • Because the kidneys clear Pepcid from the body, the Pepcid dosage must be reduced in people with poor kidney function, including kidney failure (renal failure).


  • A potentially dangerous change in the heart rhythm (known as QT prolongation) has been rarely reported in people with kidney disease whose dose of Pepcid was not adequately reduced. 


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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