GERD Home > Prevacid 24HR Warnings and Precautions

If you are thinking about taking Prevacid for heartburn that has lasted longer than three months or that occurs with dizziness or chest pain, talk to your healthcare provider -- your symptoms may be more serious than a simple case of heartburn. Other warnings and precautions with Prevacid 24HR apply to people with liver disease, women who are pregnant, and people with allergies.

What Should I Tell My Healthcare Provider?

Prior to taking Prevacid® 24HR (lansoprazole), talk to your healthcare provider if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Low blood magnesium (hypomagnesemia) 
  • Chest pain, shoulder pain, or any other heart attack symptoms
  • Frequent wheezing
  • Unexplained weight loss
  • Nausea and vomiting
  • Stomach pain
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Prevacid 24HR

Warnings and precautions to be aware of prior to taking Prevacid 24HR include the following:
  • Studies indicate that people who take proton pump inhibitor medications (such as Prevacid 24HR) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 



  • Proton pump inhibitors (PPIs), including Prevacid 24HR, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Make sure your doctor knows if you have been taking an over-the-counter (OTC) PPI drug, like Prevacid 24HR, for a long time. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. 


  • Prevacid 24HR can interact with other medications (see Prevacid 24HR Drug Interactions).
  • Be sure to see a healthcare provider if you have any symptoms that suggest your heartburn may actually be a more serious problem. Such symptoms may include:
    • Heartburn for more than three months
    • Heartburn with lightheadedness, dizziness, or sweating
    • Chest pain, shoulder pain, or any other heart attack symptoms
    • Frequent wheezing, especially with heartburn
    • Unexplained weight loss
    • Nausea and vomiting
    • Stomach pain.
  • Prevacid 24HR is considered a pregnancy Category B medication. This means that this medicine is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using Prevacid 24HR when pregnant (see Is Prevacid Safe During Pregnancy?).
  • It is unknown if Prevacid 24HR passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Prevacid and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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