GERD Home > More Medicines That Interfere With Prilosec

Certain Diuretics 
Prilosec can cause low blood magnesium (hypomagnesemia). Because certain diuretics can also cause this problem, combining Prilosec with one of these diuretics could cause severely low blood magnesium levels, which may lead to serious side effects such as muscle spasms, irregular heart rhythms, or seizures. Your healthcare provider may decide to monitor your magnesium levels periodically if you are taking Prilosec with one of these diuretics.
Prilosec may decrease the absorption of erlotinib, perhaps making it less effective. Your healthcare provider may recommend an alternative to Prilosec while you are taking erlotinib.
Escitalopram (Celexa)
Prilosec may increase the level of escitalopram in your blood, perhaps increasing your risk of escitalopram side effects. Your healthcare provider may need to decrease your escitalopram dosage to prevent this drug interaction from occurring.
HIV Medications
Prilosec can interact with some HIV medications. Depending on the medication, it could decrease the level of the medication in the blood (making it less effective) or increase the level (increasing the risk of side effects). Check with your healthcare provider before combining Prilosec with any HIV medications.
Iron Supplements
Prilosec can decrease the absorption of iron supplements into your bloodstream, perhaps making them less effective. Your healthcare provider may need to increase your iron dose as a result.
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Last reviewed by: Kristi Monson, PharmD;
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