GERD Home > More Medicines That Interfere With Prilosec
Prilosec can cause low blood magnesium (hypomagnesemia). Because certain diuretics can also cause this problem, combining Prilosec with one of these diuretics could cause severely low blood magnesium levels, which may lead to serious side effects such as muscle spasms, irregular heart rhythms, or seizures. Your healthcare provider may decide to monitor your magnesium levels periodically if you are taking Prilosec with one of these diuretics.
Prilosec may decrease the absorption of erlotinib, perhaps making it less effective. Your healthcare provider may recommend an alternative to Prilosec while you are taking erlotinib.
Prilosec may increase the level of escitalopram in your blood, perhaps increasing your risk of escitalopram side effects. Your healthcare provider may need to decrease your escitalopram dosage to prevent this drug interaction from occurring.
Prilosec can interact with some HIV medications. Depending on the medication, it could decrease the level of the medication in the blood (making it less effective) or increase the level (increasing the risk of side effects). Check with your healthcare provider before combining Prilosec with any HIV medications.
Prilosec can decrease the absorption of iron supplements into your bloodstream, perhaps making them less effective. Your healthcare provider may need to increase your iron dose as a result.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Prilosec [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP;2014 February.
Food and Drug Administration. FDA drug safety communication; low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs) (3/2/11). FDA Web site. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm245011.htm. Accessed March 17, 2011.
Clinical Pharmacology [database online]. Drug Interaction Report. Tampa, FL: Gold Standard, Inc.; 2010. Available at: http://www.clinicalpharmacology.com. Accessed March 17, 2011.
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