Prilosec is made by AstraZeneca Pharmaceuticals. Prilosec OTC is made by Proctor and Gamble.
How Does It Work?
Prilosec is part of a group of medications called proton pump inhibitors (PPIs). The stomach contains tiny pumps (called proton pumps) that produce acid. The medication works by binding to these proton pumps, stopping the production of acid. Prilosec is very effective at decreasing acid production.
Effects of Prilosec
Several studies have looked at how well Prilosec treats several conditions.
In one study for duodenal ulcers (upper intestinal ulcers), they were healed in 75 percent of people who took Prilosec after four weeks of treatment. Only 27 percent of people who were not taking the drug had their duodenal ulcer heal within four weeks. Studies have also shown that Prilosec can prevent duodenal ulcers from returning.
In studies looking at Prilosec for gastric ulcer (stomach ulcer) treatment, the drug healed the stomach ulcers in up to 82.7 percent of the people within eight weeks; ulcers healed in 48.1 percent of people who were not on the medication.
Studies have also shown that taking it in combination with certain antibiotics helps to eliminate H. pylori bacteria and to heal ulcers due to H. pylori.
GERD and Esophagitis
Studies have looked at using Prilosec for gastroesophageal reflux disease (GERD). These studies have shown that up to 56 percent of people had complete relief from their GERD symptoms, compared to 14 percent of people not taking the medication. These studies also showed that Prilosec helped to heal esophagitis (damage to the esophagus) due to GERD and helped keep erosive esophagitis from returning.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Prilosec [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP;2014 February.
Food and Drug Administration. FDA drug safety communication; low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs) (3/2/11). FDA Web site. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm245011.htm. Accessed March 17, 2011.
Clinical Pharmacology [database online]. Drug Interaction Report. Tampa, FL: Gold Standard, Inc.; 2010. Available at: http://www.clinicalpharmacology.com. Accessed March 17, 2011.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed April 16, 2010.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed May 16, 2007.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind.
Site users seeking medical advice about their specific situation should consult with their own physician. Click