GERD Home > How to Take Prilosec

Pathological Hypersecretory Conditions
Prilosec has been studied in the treatment of several pathological hypersecretory conditions, in which too much stomach acid is produced, such as Zollinger-Ellison syndrome. These studies showed that the medication is effective at decreasing the production of stomach acid and relieving symptoms.

When and How to Take It

Some general considerations for when and how to take Prilosec include the following:
  • Prilosec comes in capsule form or as packets used to mix an oral suspension (liquid). It is taken by mouth once or twice a day. The over-the-counter version is available in tablet form.
  • The medication is best taken on an empty stomach, half an hour before a meal.
  • The capsules should not be chewed or crushed, as they contain tiny granules with a special coating that prevents stomach acid from destroying the medication. Prilosec OTC tablets should not be cut, crushed, or chewed.
  • For people who have difficulty swallowing capsules, Prilosec capsules (but not tablets) can be opened and the contents sprinkled onto a spoonful of applesauce. The applesauce should not be hot and should be swallowed (without chewing) immediately.


  • For the oral suspension, the contents of one packet are mixed with a certain amount of water (which varies, depending on the strength), left to sit for two or three minutes to thicken, and taken within 30 minutes. Rinse out the container with a small amount of water and drink the contents if any of the drug remains.


  • Take your dose(s) at the same time(s) each day to maintain an even level in your blood.
  • For the medication to work properly, it must be taken as prescribed. Prilosec will not work if you stop taking it.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2020 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.