GERD Home > Important Details for Reglan

How Does It Work?

Reglan has several actions in the digestive tract. It causes the esophageal sphincter (which closes the opening from the stomach up to the esophagus) to become more tight while causing the pyloric sphincter (which closes the opening from the stomach out to the intestines) to relax. It increases the muscular contractions of the stomach and small intestines. All of these actions work together to help food move through the stomach more quickly (which is why Reglan is effective for diabetic gastroparesis treatment). Reglan has little or no activity in the colon.
Reglan helps with GERD by preventing the stomach contents from refluxing back up the esophagus, since it increases the tightness of the esophageal sphincter.
Reglan helps to relieve nausea and vomiting by blocking dopamine receptors in the brain. Dopamine can activate the part of the brain that controls nausea and vomiting, and blocking the receptors helps to alleviate nausea and vomiting symptoms.

When and How to Take Reglan

Some general considerations include the following:
  • Reglan comes in tablet, oral solution (liquid), and injectable form. The tablets are usually taken four times a day (30 minutes before meals and at bedtime). In some situations, less frequent dosing may be appropriate.
  • Reglan is not approved to be used longer than 12 weeks at a time.
  • For the medication to work properly, it must be taken as prescribed.

Dosing Information

The dose of Reglan that your healthcare provider recommends will vary depending on a number of factors, including:
  • The medical condition being treated
  • Other medical conditions you may have
  • Other medications you may currently be taking.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Reglan Dosage for more information.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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