The following sections explain in detail the potentially negative interactions that can occur when Zegerid is combined with any of the drugs listed above.
Zegerid can decrease the absorption of ampicillin into your bloodstream, perhaps making it less effective. Your healthcare provider may need to increase your ampicillin dose to prevent this interaction from occurring.
Zegerid may increase the level of cilostazol in the blood. If you must take these two medications together, your healthcare provider should consider lowering your cilostazol dosage (to perhaps 50 mg twice daily).
Taking clarithromycin and Zegerid together may increase the level of both medications in your blood. Check with your healthcare provider before taking these drugs together.
Clopidogrel is metabolized into its active form by certain liver enzymes known as CYP 2C19 enzymes. Zegerid can inhibit these enzymes, perhaps decreasing the effectiveness of clopidogrel. In general, it is usually best to avoid taking clopidogrel with Zegerid.
Zegerid can increase the level of diazepam in your blood, possibly increasing your risk of diazepam side effects. Your healthcare provider may need to decrease your diazepam dosage as a result.
Zegerid may decrease the absorption of digoxin into the bloodstream. Your healthcare provider may decide to monitor your digoxin levels using a simple blood test, especially when you start or stop taking Zegerid. Zegerid may cause low blood magnesium levels, which can lead to serious arrhythmias (irregular heart rhythms), especially in people taking digoxin. Your healthcare provider may decide to monitor magnesium levels periodically if you are taking digoxin and Zegerid.
Prilosec [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP;2012 January.
Food and Drug Administration. FDA drug safety communication; low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs) (3/2/11). FDA Web site. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm245011.htm. Accessed March 17, 2011.
Clinical Pharmacology [database online]. Drug Interaction Report. Tampa, FL: Gold Standard, Inc.; 2010. Available at: http://www.clinicalpharmacology.com. Accessed March 17, 2011.
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