GERD Home > More Info on Zegerid Indications

How Does It Work?

Zegerid belongs to a group of medications called proton pump inhibitors (PPIs). The stomach contains tiny pumps (called proton pumps) that produce acid. Zegerid works by binding to the proton pumps, stopping them from producing acid. PPIs are very effective at decreasing acid production, as they work directly at the acid pumps.
PPI medications can be destroyed by stomach acid before they have a chance to be absorbed by the body. Other PPIs get around this problem by coating the medication with special delayed-release enteric coatings (which protect the medication until it reaches the small intestine).
Zegerid is different; instead of having a delayed-release coating, the product contains sodium bicarbonate (baking soda) that acts as a buffer. This allows the medication to dissolve immediately without being destroyed by stomach acid.
It is important to note that the medication does not provide immediate benefit, as all PPIs (including Zegerid) can take a few days to start working.

Can Children Use It?

Zegerid has not been approved for children, as it has not been adequately studied in individuals under 18 years of age. Additionally, because this product comes in adult strengths and cannot be easily or accurately divided into a smaller dose (even with the packets for oral suspension), it is not an appropriate dosage for many children.

Off-Label Uses of Zegerid

On occasion, your healthcare provider may recommend Zegerid for treating something other than the conditions listed in this article. This is called an "off-label" use. Some off-label uses for Zegerid may include:
  • Preventing ulcers due to nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Treating pathological hypersecretory conditions, such as:
    • Zollinger-Ellison syndrome
    • Multiple endocrine adenomas
    • Systemic mastocytosis
    • "Short-gut" syndrome.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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