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Neem

Neem is a popular dietary supplement used for treating a variety of conditions. It appears to have anti-inflammatory, antibacterial, antifungal, and anti-fever effects. However, much more research is needed before it is fully understood how (or even if) neem works for most uses. Some of the side effects that have been reported with the supplement include jaundice, decreased urine production, and liver damage.

What Is Neem?

Neem is a tree that is commonly used for its medicinal properties. The bark, seeds, oil, leaves, and other parts of the tree are used to make a variety of different herbal remedies. Additionally, neem oil is used as a natural pesticide, and the plant's twigs are used as natural toothbrushes.
 
(Click Benefits of Neem for more information on what the supplement is used for.)
 

How Does It Work?

As a plant, neem contains many different compounds. More than 135 different compounds have been found within it. At this time, it is not clear which compounds (or combination of compounds) might be responsible for its medicinal actions. Early research suggests that neem (or the compounds found in it) has anti-inflammatory, antifungal, antibacterial, and anti-fever effects. It is thought that neem might have contraceptive effects by stimulating the immune system to attack the sperm or the embryo.
 
Much more research is necessary before it is fully understood exactly how (or even if) neem works for most uses.
 

Is Neem Effective?

It is not clear if neem is effective for most uses, as it has not been studied much in humans (see
 Does Neem Work? for more information)
.
 

Dosing Information

There is no established standard neem dosage. Recommendations from practitioners of natural medicine may vary depending on the particular use, the particular form (leaves, oil, bark, etc.), and personal experience with neem.
 
(Click Neem Dosage for more information.)
 

Potential Side Effects

Just like conventional medications, natural products can cause side effects. Some of the reported side effects of neem include, but are not limited to:
 
  • Decreased urine production
  • Yellow skin (jaundice)
  • Liver damage
  • Kidney damage.
     
(Click Neem Side Effects to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
 

Drug Interactions

Theoretically, neem may interact with other medications or supplements (see Neem Drug Interactions).
 

Is Neem Safe?

Reasonable usage of neem (at reasonable doses) is probably safe for short-term use for many people. Some people may be more likely to experience problems due to neem. Therefore, you should talk with your healthcare provider prior to taking it medicinally if you have:
 
  • Infertility
  • Diabetes
  • An autoimmune disorder, such as:

 

 

  • Any allergies, including allergies to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you:
 
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Click Is Neem Safe? for more information, including any available warnings and precautions.)
 

What If I Take an Overdose?

It is not known exactly what to expect from an overdose of this supplement. If you think you or someone else may have taken too much neem, it is important to seek immediate medical attention.
 
(Click Neem Overdose for more information.)
 

Storage Methods for Neem

Refer to the label of your individual product for information on how to best store neem supplements. Keep all medications and supplements out of the reach of children.
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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