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Nexium Drug Interactions

Certain Antifungal Medications
Combining Nexium with certain antifungals may decrease the effectiveness of the antifungal (due to decreased absorption) and may also increase the level of Nexium in the blood. Check with your healthcare provider before taking these medications together.
 
Dasatinib
Nexium may decrease the absorption of dasatinib, perhaps making it less effective. Your healthcare provider may recommend an alternative to Nexium while you are taking dasatinib.
 
Diazepam
When taking Nexium with diazepam, your body may metabolize the medicines differently than intended, although it is not believed to be significant. You may wish to discuss this with your healthcare provider, prior to starting Nexium.
 
Digoxin
Nexium may slightly increase the level of digoxin in the blood. Your healthcare provider may choose to monitor you more closely.
 
Erlotinib
Nexium may decrease the absorption of erlotinib, perhaps making it less effective. Your healthcare provider may recommend an alternative to Nexium while you are taking erlotinib.
 
Iron
Nexium may decrease the absorption of iron supplements and medications, since stomach acid is necessary for iron absorption. If you need to take iron for a medical reason (such as for anemia), your healthcare provider may recommend an alternative to Nexium.
 
Mesalamine
Nexium may interfere with the delayed-release mechanism of Apriso capsules, perhaps making Apriso less effective. This is not thought to be a problem with other mesalamine products. In general, these medications should not be taken together.
 
Some Protease Inhibitors
Nexium may decrease the level of atazanavir or nelfinavir in the blood. It may increase the level of saquinavir in the blood. If you take a protease inhibitor, check with your healthcare provider before taking Nexium. In many situations, Nexium will not be recommended.
(Nexium Drug Interactions Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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