Nexium Precautions and Warnings

For people taking Nexium, precautions and warnings to be aware of include such things as avoiding the drug while breastfeeding and being aware of potential interactions with other medications. People with liver disease may need to limit their daily dose of Nexium. Other precautions and warnings for Nexium involve not taking the drug if you are allergic to substituted benzimidazoles or Nexium itself (or any of its components).

Nexium Precautions and Warnings: What Should I Tell My Healthcare Provider?

Before taking Nexium® (esomeprazole magnesium), you should let your healthcare provider know if you:
  • Have liver disease or liver failure
  • Have low blood magnesium (hypomagnesemia) 
  • Are pregnant or breastfeeding
  • Have any allergies.
Also, tell your healthcare provider about all the medicines you may currently be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Nexium Precautions and Warnings

Some precautions and warnings to be aware of with Nexium include the following:
  • Studies indicate that people who take proton pump inhibitor medications (such as Nexium) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 


  • Nexium can interact with certain medications (see Nexium Drug Interactions).
  • Nexium is considered a pregnancy category B drug. This means that it has not been studied in pregnant women. However, when studied in animals, it showed no negative effects on unborn babies. Discuss the safety of taking Nexium with your healthcare provider before starting the medication.
  • If you have severe liver disease, you should not exceed a daily dose of Nexium 20 mg.


  • Proton pump inhibitors (PPIs), including Nexium, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. 


  • Based on information about omeprazole (Prilosec®), a similar drug, it is likely that Nexium passes through breast milk. Talk with your doctor before taking this drug while breastfeeding.
The Dirty, Messy Part of BPH

Nexium Medication

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