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Pepcid Drug Interactions

When certain medications are combined with Pepcid, drug interactions may occur. Some of the medicines that can potentially interact with Pepcid include atazanavir, ketoconazole, and itraconazole. If Pepcid drug interactions are a concern, your healthcare provider may alter your doses of some medications or may suggest an alternative to Pepcid.

 

Pepcid Drug Interactions: An Overview

Pepcid® (famotidine) can potentially interact with a few other medicines. Some of the medicines that may lead to Pepcid interactions include:
 

Pepcid Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Pepcid is combined with any of the drugs listed above.
 
 
Atazanavir
Taking Pepcid with atazanavir can decrease the absorption of atazanavir into the body, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to increase your dose of atazanavir or may suggest an alternative to Pepcid.
 
Itraconazole
Combining Pepcid with itraconazole can decrease the absorption of itraconazole into the body, which may make it less effective. To prevent this, your healthcare provider may need to increase your dose of itraconazole or may suggest an alternative to Pepcid.
 
Ketoconazole
Taking Pepcid with ketoconazole can decrease the absorption of ketoconazole into the body, perhaps making it less effective. Depending on your particular situation, your healthcare provider may need to increase your dose of ketoconazole or may suggest a substitution for Pepcid.
 
(Pepcid Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;