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Prilosec Interactions

Escitalopram (Celexa)
Prilosec may increase the level of escitalopram in your blood, perhaps increasing your risk of escitalopram side effects. Your healthcare provider may need to decrease your escitalopram dosage to prevent this drug interaction from occurring.
 
HIV Medications
Prilosec can interact with some HIV medications. Depending on the medication, it could decrease the level of the medication in the blood (making it less effective) or increase the level (increasing the risk of side effects). Check with your healthcare provider before combining Prilosec with any HIV medications.
 
Iron Supplements
Prilosec can decrease the absorption of iron supplements into your bloodstream, perhaps making them less effective. Your healthcare provider may need to increase your iron dose as a result.
 
Ketoconazole (Nizoral)
Prilosec can decrease the absorption of ketoconazole into your bloodstream, perhaps making it less effective. Your healthcare provider may need to increase your ketoconazole dosage to prevent this interaction from occurring.
 
Phenytoin (Dilantin, Phenytek)
Prilosec can increase the level of phenytoin in your blood, increasing your risk of phenytoin side effects. Your healthcare provider may need to decrease your phenytoin dosage to prevent this.
 
Tacrolimus (Prograf)
Prilosec can increase the level of tacrolimus in your blood, which could increase your risk of tacrolimus side effects. Your healthcare provider may need to check your blood level and adjust your dose of tacrolimus as necessary.
 
Voriconazole (Vfend)
Voriconazole can double the amount of Prilosec in your blood, increasing your risk of side effects. Typically, this is a significant problem only for people taking a high Prilosec dosage. However, you should talk to your healthcare provider before using these medications together.
  
Warfarin (Coumadin, Jantoven)
Prilosec can increase the level of warfarin in your blood, increasing your risk of bleeding. Your healthcare provider should monitor you closely and adjust your warfarin dose as necessary.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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