Drug Combinations With Prilosec to Avoid

Prilosec Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Prilosec is combined with any of the drugs listed above.
 
Ampicillin (Principen)
Prilosec can decrease the absorption of ampicillin into your bloodstream, perhaps making it less effective. Your healthcare provider may need to increase your ampicillin dose to prevent this interaction from occurring.
 
Cilostazol
Prilosec may increase the level of cilostazol in the blood. If you must take these two medications together, your healthcare provider should consider lowering your cilostazol dosage (to perhaps 50 mg twice daily).
  
Citalopram (Celexa)
Prilosec may increase the level of citalopram in your blood, perhaps increasing your risk of citalopram side effects. Your healthcare provider may need to decrease your citalopram dosage to prevent this.
 
Clopidogrel (Plavix)
Some research suggests that Prilosec may decrease the effectiveness of clopidogrel. This could potentially be a serious drug interaction. However, experts are still in disagreement about how significant this interaction really is. Do not combine these medications without discussing the matter with your healthcare provider first.
  
Diazepam (Valium)
Prilosec can increase the level of diazepam in your blood, possibly increasing your risk of diazepam side effects. Your healthcare provider may need to decrease your diazepam dosage as a result.
 
Digoxin
Prilosec may decrease the absorption of digoxin into the bloodstream. Your healthcare provider may decide to monitor your digoxin levels using a simple blood test, especially when you start or stop taking Prilosec. Prilosec may cause low blood magnesium levels, which can lead to serious arrhythmias (irregular heart rhythms), especially in people taking digoxin. Your healthcare provider may decide to monitor your magnesium levels periodically if you are taking digoxin and Prilosec.
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Prilosec Medicine

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