Additional Drugs That React With Prilosec

Ketoconazole (Nizoral)
Prilosec can decrease the absorption of ketoconazole into your bloodstream, perhaps making it less effective. Your healthcare provider may need to increase your ketoconazole dosage to prevent this interaction from occurring.
 
Methotrexate
Prilosec might increase the level of methotrexate in the blood, increasing the risk for methotrexate side effects. Check with your healthcare provider before combining these two medications.
  
Phenytoin (Dilantin, Phenytek)
Prilosec can increase the level of phenytoin in your blood, increasing your risk of phenytoin side effects. Your healthcare provider may need to decrease your phenytoin dosage to prevent this.
 
Rifampin
Rifampin may significantly decrease the level of Prilosec in the blood, making it less effective. These medications should not be combined.
 
St. John's Wort
St. John's wort may significantly decrease the level of Prilosec in the blood, making it less effective. These medications should not be combined. 
 
Tacrolimus (Prograf)
Prilosec can increase the level of tacrolimus in your blood, which could increase your risk of tacrolimus side effects. Your healthcare provider may need to check your blood level and adjust your dose of tacrolimus as necessary.
 
Voriconazole (Vfend)
Voriconazole can double the amount of Prilosec in your blood, increasing your risk of side effects. Typically, this is a significant problem only for people taking a high Prilosec dosage. However, you should talk to your healthcare provider before using these medications together.
  
Warfarin (Coumadin, Jantoven)
Prilosec can increase the level of warfarin in your blood, increasing your risk of bleeding. Your healthcare provider should monitor you closely and adjust your warfarin dose as necessary.
 
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