Prilosec Warnings and Precautions

To ensure a safe treatment process, it is important to be aware of the risks of taking Prilosec. Warnings and precautions to be aware of with the medication include potential drug interactions, the safety of taking the drug while pregnant or breastfeeding, and being aware that the symptoms of ulcers and heartburn are similar to those of stomach cancer. Prilosec is not suitable for everyone; you should not take Prilosec if you are allergic to any of the ingredients used to make the medicine.

Prilosec: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Prilosec® (omeprazole) if you have:
  • Liver disease, including liver failure or cirrhosis
  • Low blood magnesium (hypomagnesemia) 
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Prilosec Warnings and Precautions

Some of the warnings and precautions to be aware of prior to taking Prilosec include the following:
  • Studies indicate that people who take proton pump inhibitor medications (such as Prilosec) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 


  • Some of the symptoms of GERD, heartburn, and ulcers are similar to the symptoms of stomach cancer. Just because Prilosec helps your symptoms does not rule out the possibility of stomach cancer.
  • Tell your healthcare provider if you have liver disease, as Prilosec is generally not recommended for those with severe liver problems.


  • Proton pump inhibitors (PPIs), including Prilosec, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. 


  • Prilosec can interact with other medications (see Prilosec Interactions).
  • Prilosec is considered a pregnancy Category C medication. This means Prilosec may not be safe for use during pregnancy. Talk to your healthcare provider about the risks and benefits of using Prilosec during pregnancy (see Prilosec and Pregnancy).
  • Prilosec passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Prilosec and Breastfeeding).
The Dirty, Messy Part of BPH

Prilosec Medicine

Referring Pages:
Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2020 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.