Protonix Precautions and Warnings

For people taking Protonix, precautions and warnings to be aware of include a slight risk of developing a vitamin B12 deficiency while taking the medication. Other precautions and warnings for Protonix users include not breastfeeding while taking the drug and being aware of possible interactions involving Protonix and other medications.

Protonix Precautions and Warnings: What Should I Tell My Healthcare Provider?

Before taking Protonix® (pantoprazole sodium), let your healthcare provider know if you:
  • Have liver disease or liver failure
  • Have low blood magnesium (hypomagnesemia) 
  • Are pregnant or breastfeeding
  • Have any allergies.
Be sure to tell your healthcare provider about all of the medicines that you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Protonix Precautions and Warnings

Precautions and warnings to be aware of with Protonix include the following:
  • Studies indicate that people who take proton pump inhibitor medications (such as Protonix) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 


  • Proton pump inhibitors (PPIs), including Protonix, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. 


  • Protonix is considered a pregnancy Category B drug. This means that it has not been studied in pregnant women. However, when studied in animals, it showed no negative effects on unborn babies. If you are pregnant, talk to your healthcare provider about whether Protonix is safe for you and your baby.
  • It is not known whether Protonix passes through milk when a woman is nursing. Therefore, women taking Protonix should avoid nursing while on the medication.
  • In general, acid suppressing medications may interfere with the absorption of vitamin B12, which means that there is a slight risk of developing a B12 deficiency. Discuss this with your healthcare provider if you have concerns.
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Protonix Medication

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