Reglan Warnings and Precautions

Let your healthcare provider know if you have high blood pressure, epilepsy, or any allergies before using Reglan. Warnings and precautions for the drug should also be discussed with your healthcare provider, as Reglan can cause a number of side effects, including extrapyramidal symptoms, neuroleptic malignant syndrome, and depression. You should not take Reglan if you have gastrointestinal bleeding, perforation, or blockage.

Reglan: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Reglan® (metoclopramide) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Reglan

Some warnings and precautions to be aware of with Reglan include the following:
  • Reglan can cause depression. Some cases are mild, while others are quite severe and may involve suicidal thinking or behavior. Make sure to tell your healthcare provider if you have depression or even a history of depression. If you start to notice any depression symptoms while taking Reglan, contact your healthcare provider right away.
  • Reglan can cause a group of very bothersome and sometimes disturbing side effects known as extrapyramidal symptoms (EPS). These symptoms include:


    • Unusual body, facial, or tongue movements
    • Muscle tension or contractions
    • Feelings of internal restlessness or jitteriness. 
It is important to let your healthcare provider know right away if you develop EPS, since letting it go too long increases the chance of the symptoms becoming permanent, even after the medication is stopped.
  • Reglan can cause symptoms that look like Parkinson's disease. It can also make Parkinson's disease worse. In general, people with Parkinson's disease should avoid taking Reglan.
  • Reglan can cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include:


    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • A fast heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias)


        Tell your healthcare provider right away if think you might have NMS.


  • Reglan may make high blood pressure, congestive heart failure, and cirrhosis worse. If you have any of these conditions, check with your healthcare provider before taking Reglan.
  • Some people may experience withdrawal symptoms (such as dizziness, nervousness, or headaches) after stopping Reglan.
  • Reglan can interact with other medications (see Reglan Interactions).
  • Reglan is usually considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using Reglan during pregnancy (see Reglan and Pregnancy for more information).
  • Reglan passes through breast milk. Therefore, if you are breastfeeding or plan to start, be sure to talk with your healthcare provider about using Reglan (see Reglan and Breastfeeding for more information).
Diabetes Tips for Seniors

Reglan Medication Information

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