Products That Can React With Sucralfate

Drug Interactions With Sucralfate Explained

The following sections explain in detail the potentially negative interactions that can occur when sucralfate is combined with any of the drugs listed above.
 
Aluminum-Containing Antacids
Sucralfate contains aluminum. Normally, the small amount of aluminum from sucralfate that is absorbed into the body is easily removed by the kidneys (unless a person has kidney disease). Taking other aluminum-containing antacids increases the body's exposure to aluminum, which could perhaps cause problems. Check with your healthcare provider before taking sucralfate with any antacid that contains aluminum.
 
Anagrelide
Sucralfate may decrease the level of anagrelide in the blood, perhaps making it less effective. Check with your healthcare provider before taking these medications together.
 
Azole Antifungals
Sucralfate may bind to azole antifungals in the digestive tract, decreasing their absorption into the bloodstream (perhaps making them less effective). Separating sucralfate and the antifungal by at least two hours helps to minimize this interaction.
 
Cimetidine
Sucralfate may bind to cimetidine in the digestive tract, decreasing its absorption into the bloodstream (perhaps making it less effective). Separating sucralfate and cimetidine by at least two hours helps to minimize this interaction.
 
Digoxin
Sucralfate may bind to digoxin in the digestive tract, decreasing its absorption into the bloodstream (perhaps making it less effective). Make sure to take digoxin at least two hours before or at least six hours after taking sucralfate.
 
Eltrombopag
Sucralfate may decrease the level of eltrombopag in the blood, perhaps making it less effective. Separating sucralfate and eltrombopag by at least four hours helps to minimize this interaction.

Sucralfate Drug Information

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