Sucralfate Overdose

When large doses of sucralfate (Carafate) were administered in animal studies, researchers were unable to find a lethal dose. Although the specific effects of a sucralfate overdose will vary, it is theoretically possible that taking too much of this medication could cause aluminum toxicity. If an overdose did occur, treatment would likely focus on treating any resulting symptoms.

Can You Take Too Much Sucralfate?

Sucralfate (Carafate®) is a prescription ulcer medication. An overdose of this medicine does not appear to be particularly dangerous. The specific effects of an overdose will vary, depending on a number of factors, including the sucralfate dosage and whether it was taken with any other medications or substances.
 

Effects of an Overdose

In animal studies, researchers were unable to find a lethal dose. This means that even exceptionally large doses were not lethal. This makes sense, as very little of the medication is actually absorbed from the digestive tract.
 
However, because sucralfate does contain some aluminum, it is theoretically possible that an overdose (especially a chronic overdose) could cause aluminum toxicity. This is most likely to occur in people with kidney disease (normally, the kidneys easily remove aluminum from the body).
 
Signs and symptoms of aluminum toxicity are usually subtle and develop over a long period of time. Some of these signs and symptoms might include:
 
  • Weak bones
  • Muscle and bone pain
  • Confusion or other mental changes.
     
Aluminum toxicity due to a one-time overdose would not be expected, especially in an individual with normal kidney function.
 

Treatment for a Sucralfate Overdose

At this time, there are no specific treatments recommended for an overdose with sucralfate. Therefore, treatment will involve supportive care, which consists of carefully monitoring for any possible problems and treating any problems that occur. There is no specific antidote for this type of overdose.
 
It is important that you seek medical attention immediately if you believe that you may have overdosed on sucralfate.
 
 

Sucralfate Drug Information

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